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Abstract Aims The aim of this exploratory study was to investigate associations between irinotecan pharmacokinetic parameters and allelic variants in genes encoding for drug transporters and drug metabolizing enzymes that are involved in irinotecan disposition in Asian patients with cancer. Of the six candidate genes that were analyzed, Ads Waldorf men seeking men genetic variants were. ificant genotypic—phenotypic associations were apparent only for transporter genes.

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